What Works
* There is a script, offlineObf-win.py, which will take as input a CMT-style obf external and obf-version-specific text file and create a reorganized one which SCons can understand.
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This one is very messy and I have no good ideas how to break off a discrete piece of it for someone else to work on. If there is anyone willing to put some serious time and effort into learning about the problem problems* and working on a solution, I'd welcome a partner.
* I think there are at least two: coming up with a reliable, comprehensible mechanism for generating a set-up file and understanding what's involved in dealing with machines with multiple installations of Studio.