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Installation on my rhel5 laptop was straightforward, as was creating and starting up a VM using the gui application. The only hitch was that redhat4 - actually the Scientific Linux equivalent - did not make a good guest: it failed to boot. SL5 and SL6 guests are ok. The VirtualBox doc warns about this. Kernels that kernels which are too old, including the one in rhel4, have problems. In fact, they also discourage use of 2.6.18 (rhel5 and SL5 kernel) in the guest, claiming it suffers from race conditions at boot, but I haven't had any problems with it. seen any signs of that.